To help educators provide students with the scientific literacy and hands-on experience needed for college and STEM careers, PASCO® Scientific commissioned a white paper to review the research and expert opinion related to high-quality, engaging science instruction. Titled, “Meeting the World’s Needs for 21st Century Science Instruction,” the paper examines the worldwide need for more qualified scientists, medical professionals, engineers and technologists, and the call for students to be more scientifically literate and experienced with science tools and practices. It further explores the positive impact that hands-on, inquiry-based instruction and technology tools have on increasing students’ understanding, as well as their motivation and interest in science.